Black patients have higher rates of death after PCI

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Woman patient

Black patients who undergo percutaneous coronary intervention (PCI) are at an increased risk for major adverse outcomes, including death, compared to white patients, according to a study published in JACC: Cardiovascular Interventions. A press release from the American College of Cardiology (ACC) says the study underscores the high rates of cardiovascular disease and risk factors in minorities and the continued need for further research on race-based outcomes after cardiovascular procedures, including PCI, to understand and alleviate these differences.

Although previous studies have suggested that short- and long-term outcomes after PCI vary by race and cannot be fully explained by different baseline risk factors and treatment characteristics, other studies have failed to show a significant association. Furthermore, as current race-based PCI outcomes have been acquired from registries and single-centre studies lacking central monitoring and event adjudication, the authors of the study sought to assess the presence of racial disparities in clinical characteristics and outcomes from a large patient-level pooled database.

The researchers used data from the Cardiovascular Research Foundation to analyse 10 prospective, randomised controlled trials with a combined total of 22,638 patients classified by race who underwent PCI. There were 20,585 (90.9%) white patients (reference group), 918 (4.1%) Black patients, 404 (1.8%) Asian patients, and 473 (2.1%) Hispanic patients. Other races were excluded from the analysis due to small sample sizes. Baseline characteristics such as body mass index (BMI) and PCI outcomes at 30 days, one-year, and five-years were assessed. Principal outcomes of interest were all-cause death, myocardial infarction (MI), and major adverse cardiac events (MACE), defined as the composite of cardiac death, MI or ischaemia-driven target lesion revascularisation.

In the five-year follow up after PCI, the MACE rates were 23.9% in Black patients compared with 18.8% in white patients, 21.5% in Hispanic patients and 11.2% in Asian patients. Multivariable analysis demonstrated an independent association between Black patients and five-year risk of MACE following PCI. Black patients also had higher rates of death in both the one- and five-year follow-ups after PCI compared to any other group. Results from the analysis showed that while enrolled in PCI, both Black and Hispanic patients had greater cardiovascular risk factors—including diabetes, hypertension, and hyperlipidaemia— than white and Asian patients.

Gregg W Stone (Icahn School of Medicine at Mount Sinai, New York, USA), senior author of the study, comments in the press release: “The variables that may contribute to the greater cardiovascular risks in minorities are multifactorial. The variables include risk factors for example, greater hypertension, smoking and diabetes, and differences in body mass index), differences in cardiac structure (for example, coronary artery size and left ventricular mass) and socioeconomic considerations (for example, reduced access to care and/or insurance coverage, lack of preventative care, disease awareness and education, delayed presentation when ill, and in some studies varying provision of care).”

He adds: “I am hopeful that the increased societal attention to racial disparities prompted by recent social injustices will translate to improve health care and outcomes for minorities. But it won’t just happen without active concerted efforts to promote change and opportunity, a task for government, regulators, payors, hospital administrators, physicians, and all health care providers.”

This study has several limitations, including Black and Hispanic patients were underrepresented in the trials so there is a potential for some selection bias; socioeconomic factors were not captured, which may influence differences in the risk of adverse outcomes after PCI; and the term “Hispanic” was designated as a race and not ethnicity, thereby potentially limiting the differences in outcomes between Hispanics and other races. Because this study included racial disparities in the three largest minority groups, further studies are required to address other minority groups and ethnicities/subgroups.

In an accompanying editorial comment, Eric D Peterson (Duke University School of Medicine, Durham, USA), says the study findings serve as a reminder of how large the racial gaps in cardiovascular disease treatments and outcomes are and continue to be: “Solving racial health disparities is a crucial and pressing priority for all in health care. We must all commit to reversing racial health disparities for tomorrow’s generation. Talking is no longer enough; it is our responsibility to finally deliver effective solutions.”


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