Performing percutaneous coronary intervention (PCI) significantly improved outcomes in patients with stable coronary artery disease (CAD) and severe aortic stenosis selected for transcatheter aortic valve implantation (TAVI), results of the NOTION-3 trial have shown.
NOTION-3 randomised patients selected for TAVI for severe aortic stenosis with at least one physiologically significant PCI-eligible coronary artery stenosis to either complete revascularisation with PCI in addition to TAVI or conservative management with TAVI alone.
The trial’s primary endpoint—death, myocardial infarction (MI), or urgent revascularisation, was significantly reduced in the PCI cohort compared with TAVI alone, though investigators saw an increase in bleeding events in the investigational group.
Here, the trial’s principal investigator, Jacob Lønborg (Copenhagen University Hospital, Copenhagen, Denmark) tells Cardiovascular News why he believes the trial’s results add weight to the argument that performing PCI should be the standard of care among these patients.
