In this PCR video, David E Kandzari (Department of Interventional Cardiology, Piedmont Heart Institute, Atlanta, USA) speaks to Atul Pathak (National Institute of Health and Medical Research, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France) about the implications of the SPYRAL HTN-ON MED study, which Kandzari presented at EuroPCR (22-25 May, Paris, France) and published in the Lancet.